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KMID : 0383820070620010043
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Tuberculosis and Respiratory Diseases
2007 Volume.62 No. 1 p.43 ~ p.50
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Immunohistochemical Study of C-erbB-2 and VEGF Expression in Non-Small Cell Lung Cancer
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Shin Jong-Wook
Choi Jae-Cheol
Kim Jae-Yeol
Park In-Won
Choi Byoung-Whui
Yoo Jae-Hyung
Ha Kyung-Won
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Abstract
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Background: Mutated or deregulated expression of C-erbB-2 causes this gene to function as a potent oncogene. Vascular endothelial growth factor (VEGF) is a crucial angiogenic molecule in lung cancer. Both C-erbB-2 and VEGF can promote growth, proliferation and metastasis in non-small cell lung cancer (NSCLC). The purpose of this study was to investigate evaluate the relationship between the expressions of the C-erbB-2 and VEGF genes using immunohistochemistry.
Materials and Methods : Ninety-five patients with NSCLC were involved (60 squamous cell carcinoma and 35 adenocarcinoma). The formalin-fixed paraffin embedded specimens were immunohistochemically stained for C-erbB-2 and VEGF using the avidin-biotin complex method.
Results : Positive C-erbB-2 expression was observed more often in adenocarcinomas than squamous cell carcinomas (p<0.05). Although the immunohistochemical expressions of C-erbB-2 and VEGF in non-small-cell lung cancer showed increased tendencies at an advanced stage, the correlation between early and advanced cancers was insignificant. In adenocarcinomas, the expressions of VEGF and C-erbB-2 were significantly (p<0.05).
Conclusion: The overexpression fo C-erbB-2 was significantly higher in adenocarcinomas than squamous cell carcinomas, and correlated with the expression of VEGF in adenocarcinomas of the lungs.
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KEYWORD
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C-erbB-2, VEGF, Non-small-cell Lung cancer
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